Elevated pCO2 affects the lactate metabolic shift in CHO cell culture processes
نویسندگان
چکیده
منابع مشابه
Multidisciplinary Analysis of the Metabolic Shift to Lactate Consumption in CHO Cell Culture
Mammalian cells represent the most widely used host system for the industrial production of recombinant therapeutic proteins. In order to increase productivity, chemically defined media are often used and optimized to provide the cells with the necessary nutrients. However, a deregulated cell metabolism is often observed in these culture conditions. In particular, carbon sources are fast and in...
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ژورنال
عنوان ژورنال: Engineering in Life Sciences
سال: 2017
ISSN: 1618-0240
DOI: 10.1002/elsc.201700131